Alexander LEZHAVA

RESEARCH

Selected Publications

• Suzuki Y, Ng SB, Chua C, Leow WQ, Chng J, Liu SY, Ramnarayanan K, Gan A, Ho DL, Ten R, Su Y, Lezhava A, Lai JH, Koh D, Lim KH, Tan P, Rozen SG, Tan IB "Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer." Mol Oncol 2017 Feb ; 11(2) : 124-139 Abstract
• Wang SR, Malik S, Tan IB, Chan YS, Hoi Q, Ow JL, He CZ, Ching CE, Poh DY, Seah HM, Cheung KH, Perumal D, Devasia AG, Pan L, Ang S, Lee SE, Ten R, Chua C, Tan DS, Qu JZ, Bylstra YM, Lim L, Lezhava A, Ng PC, Wong CW, Lim T, Tan P "Technical Validation of a Next-Generation Sequencing Assay for Detecting Actionable Mutations in Patients with Gastrointestinal Cancer." J Mol Diagn 2016 May ; 18(3) : 416-24 Abstract
• Yoshida K, Takano J, Ishizu Y, Lezhava A, Ieiri I, Maeda K, Hayashizaki Y, Sugiyama Y "Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method." AAPS J 2013 Apr ; 15(2) : 618-22 Epub 2013 Mar 8 Abstract
• Kawai Y, Kimura Y, Lezhava A, Kanamori H, Usui K, Hanami T, Soma T, Morlighem JÉ, Saga S, Ishizu Y, Aoki S, Endo R, Oguchi-Katayama A, Kogo Y, Mitani Y, Ishidao T, Kawakami C, Kurata H, Furuya Y, Saito T, Okazaki N, Chikahira M, Hayashi E, Tsuruoka S, Toguchi T, Saito Y, Ban T, Izumi S, Uryu H, Kudo K, Sakai-Tagawa Y, Kawaoka Y, Hirai A, Hayashizaki Y, Ishikawa T "One-step detection of the 2009 pandemic influenza A(H1N1) virus by the RT-SmartAmp assay and its clinical validation." PLoS One 2012 ; 7(1) : e30236 Epub 2012 Jan 25 Abstract
• Kimura Y, de Hoon MJ, Aoki S, Ishizu Y, Kawai Y, Kogo Y, Daub CO, Lezhava A, Arner E, Hayashizaki Y "Optimization of turn-back primers in isothermal amplification." Nucleic Acids Res 2011 May ; 39(9) : e59 Epub 2011 Feb 9 Abstract
• Lezhava A, Ishidao T, Ishizu Y, Naito K, Hanami T, Katayama A, Kogo Y, Soma T, Ikeda S, Murakami K, Nogawa C, Itoh M, Mitani Y, Harbers M, Okamoto A, Hayashizaki Y "Exciton Primer-mediated SNP detection in SmartAmp2 reactions." Hum Mutat 2010 Feb ; 31(2) : 208-17 Abstract
• Toyoda Y, Sakurai A, Mitani Y, Nakashima M, Yoshiura K, Nakagawa H, Sakai Y, Ota I, Lezhava A, Hayashizaki Y, Niikawa N, Ishikawa T "Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?" FASEB J 2009 Jun ; 23(6) : 2001-13 Epub 2009 Apr 21 Abstract
• Aomori T, Yamamoto K, Oguchi-Katayama A, Kawai Y, Ishidao T, Mitani Y, Kogo Y, Lezhava A, Fujita Y, Obayashi K, Nakamura K, Kohnke H, Wadelius M, Ekström L, Skogastierna C, Rane A, Kurabayashi M, Murakami M, Cizdziel PE, Hayashizaki Y, Horiuchi R "Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2." Clin Chem 2009 Apr ; 55(4) : 804-12 Epub 2009 Jan 30 Abstract
• Hoshi K, Takakura H, Mitani Y, Tatsumi K, Momiyama N, Ichikawa Y, Togo S, Miyagi T, Kawai Y, Kogo Y, Kikuchi T, Kato C, Arakawa T, Uno S, Cizdziel PE, Lezhava A, Ogawa N, Hayashizaki Y, Shimada H "Rapid detection of epidermal growth factor receptor mutations in lung cancer by the SMart-Amplification Process." Clin Cancer Res 2007 Sep 1 ; 13(17) : 4974-83 Abstract
• Mitani Y, Lezhava A, Kawai Y, Kikuchi T, Oguchi-Katayama A, Kogo Y, Itoh M, Miyagi T, Takakura H, Hoshi K, Kato C, Arakawa T, Shibata K, Fukui K, Masui R, Kuramitsu S, Kiyotani K, Chalk A, Tsunekawa K, Murakami M, Kamataki T, Oka T, Shimada H, Cizdziel PE, Hayashizaki Y "Rapid SNP diagnostics using asymmetric isothermal amplification and a new mismatch-suppression technology." Nat Methods 2007 Mar ; 4(3) : 257-62 Epub 2007 Feb 18 Abstract