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Bioprocessing Technology Institute

The Bioprocessing Technology Institute (BTI) is a national research institute funded by A*STAR with core expertise in bioprocess science and engineering. Established in 1990 as the Bioprocessing Technology Unit, it was renamed the Bioprocessing Technology Institute (BTI) in 2003.

BTI has integrated capabilities to accelerate innovation in biologics, cell and gene therapy, and cultured meat.

SEAMLESS INTEGRATION, BORDERLESS INNOVATION

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PRODUCT INNOVATION

By incorporating manufacturability and regulatory considerations early in research, BTI innovates novel biological products that include antibodies, exosomes, gene therapy, cell therapy, and alternative proteins for food.

CELL LINE DEVELOPMENT

BTI leverages expertise in both mammalian and microbial expression systems to optimise yield and quality of biological products by vector and cellular engineering. Cell lines and technologies are available for licensing.

MEDIA DEVELOPMENT

BTI employs state-of-the-art systems and algorithms to optimise culture media composition and feed strategies. Serum-free, xeno-free, protein-free, and chemically defined formulations have been developed in-house or with industry partners.

DOWNSTREAM PROCESSING

A comprehensive suite of technologies from cell clarification, filtration, chromatography, virus inactivation, to sterilisation enables BTI to adopt industry standards for scalable isolation and purification of biological products.

PROCESS DEVELOPMENT & SCALE-UP

BTI’s infrastructure permits scale-up and integration of unit operations up to 50 litres in pre-cGMP settings. Both single- and multi-use modalities are available for preclinical process development. BTI actively develops scaled-down models for selected unit operations.

ANALYTICAL SCIENCE & TECHNOLOGIES

BTI performs deep characterisation of bioprocesses and products to improve yield, quality and safety. Novel sensors and virtual models are being developed to better understand, monitor, and control the bioprocess.

Talent Development for Industry

An important component of BTI is the development of resourceful science and engineering graduates through on-the-job training and post-graduate programmes by A*STAR Graduate Academy and other Institutes of Higher Learning. Our skilled talents have secured key positions in local and overseas companies in biotechnology and biomanufacturing sectors.