Analytical Science & Technology (GlycoAnalytics)
ASSESSING AND ENSURING PRODUCT SAFETY AND QUALITY
The GlycoAnalytics group focuses on the assessment of product safety and quality through product and process analysis. Our group can accurately and quickly characterise critical quality attributes (CQAs) such as: glycans, protein aggregation, charge variants, sequence variants and protein topology. We strive to develop new methods and platforms for rapid, more detailed CQA characterisation at higher throughput to strengthen the development of novel drugs and biosimilars in Singapore. Furthermore, the team has developed mathematical/computational models, algorithms, software, and databases to help with automating, monitoring and analysing product CQAs.
- Glycan profiling, N-/O- site occupancy and glycosylation associated CQAs for glycoprotein drugs
- Rapid semi-automated platform for accurate characterisation of product safety and CQAs
- Aggregation characterisation and data-driven mathematical models that can simulate how different processing conditions influence aggregation
- Machine learning modelling towards Quality by Design (QbD), predictive models and biomanufacturing 4.0, in partnership with other BTI research groups
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