Our Capabilities
Clog-free Perfusion Filter Systems
- Provide expertise and insights into bioprocessing, microfluidic phenomena, and various engineering disciplines
- Knowledge in developing perfusion filters which enable clog-free, high throughput operations and removal of dead cells
Integrated Solutions for Future Biomanufacturing
- Accumulated multi-disciplinary knowhow for the development of cross-cutting engineering solutions
- Integrated solutions for automated microfluidic sampling, in-line or at-line monitoring and real-time data analytics, with adaptive control to ensure critical process parameters (CPPs)
Our Technologies
Zero Clogging High Density Cell Filter – uVisflo
Our proprietary in-house cell retention filter, uVisflo, overcomes the problem of biofouling and clogging that often occurs in traditional membrane-based filters, especially for high density cultures used in biomanufacturing. Our membrane-free technology has the has the following capabilities:
- Clog-free – No biofouling.
- Ultra-high density – Up to 100 million cells/mL.
- Enhances viability – Increase viability by 5% of bioreactor for every filtration operation.
Tube-free Microfluidic Switchboards
We have combined several microfluidic components with programmable digital pneumatics, to achieve precise switching and controlled fluidic flows. These microfluidic switchboards can be further equipped with novel biosensors, creating a fully integrated platform for continuous processing. The integrated platform offers the following advantages:
- Minimal sample volumes and tube-free operations.
- High throughput and programmability.
- Miniaturization of multiple lab scale functionalities into microfluidic devices.
- High precision switching, control and sensitivity.
- Real-time data monitoring to ensure critical process parameters (CPPs) for in-process learning and automated online processes.
- Integrated microfluidic modules for functional versatility, diversity and optimal adaptive control.
Our Track Record
Featured Publications
- An Eng Lim and Shireen Goh (2023) Effect of Microchannel Diameter on Electroosmotic Flow Hysteresis. Energies 16(5): 2154
- Danielle S. Tan and Shireen Goh (2016) A Numerical Model of Microfluidic Inertial Separation. In Proceedings of the 20th Australasian Fluid Mechanics Conference, AFMC 2016
- Shireen Goh, Shan Mei Tan, Danielle S. Tan, Yuan Sheng Yang (2016) New phenomenon: Outer wall focusing at high cell densities enables high performance cell microfilter at low shear stress. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, C.
- Gajendra P. Singh, Shireen Goh, Michelangelo Canzoneri and Rajeev J. Ram (2015) Raman spectroscopy of complex defined media: biopharmaceutical applications. Journal of Raman Spectroscopy 46(6): 545-550
- Wee Yang Ng, Shireen Goh, Yee Cheong Lam, Chun Yang and Isabel Rodríguez (2009) DC-biased AC-electroosmotic and AC-electrothermal flow mixing in microchannels. Lab On A Chip 9: 802-809
- Sheng Shen, Arvind Narayanaswamy, Shireen Goh and Gang Chen (2008) Thermal conductance of bimaterial microcantilevers. Applied Physics Letters 92: 063509
- Saikat Ghosh, Amar R. Bhagwat, C. Kyle Renshaw, Shireen Goh, Alexander L. Gaeta, and Brian J. Kirby (2006) Low-Light-Level Optical Interactions with Rubidium Vapor in a Photonic Band-Gap Fiber. Physical Review Letters 97: 023603
LANDMARK PATENT & IP:
- Small Volume Bioreactors with Substantially Constant Working Volumes and Associated Systems and Methods (2020)
- Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereof (2018)
- Control of Carbon Dioxide Levels and pH in Small Volume Reactors (2014)
- Humidity Control in Chemical Reactors (2014)
The Team
Dr Lim An Eng
lim_an_eng@bti.a-star.edu.sg
Scientist
PhD in Mechanical Engineering (2018), Nanyang Technological University, Singapore
Research Focus / Interest
- Micro-/nanofluidics
- Micro-/nanofabrication
- Electrokinectics
- Multiphase flow for chemical analysis
- Nanomaterials engineering for DNA analysis
- Automatic aseptic sampling for bioreactors
Dr Sitaram Gupta Vangeti
sitaram_gupta_vangeti@bti.a-star.edu.sg
Scientist
PhD in Biomedical Engineering (2022), Indian Institute of Science (IISc), Bangalore, India
Research Focus / Interest
- Microfabrication
- Biomedical device development
- MEMS technology
- Electronic system design
- Development of automation systems for bioprocess applications