Biomanufacturing Devices

• Provide expertise and insights into bioprocessing, microfluidic phenomena, and various engineering disciplines
• Knowledge in developing perfusion filters which enable clog-free, high throughput operations and removal of dead cells

• Accumulated multi-disciplinary knowhow for the development of cross-cutting engineering solutions
• Integrated solutions for automated microfluidic sampling, in-line or at-line monitoring and real-time data analytics, with adaptive control to ensure critical process parameters (CPPs)

Our proprietary in-house cell retention filter, uVisflo, overcomes the problem of biofouling and clogging that often occurs in traditional membrane-based filters, especially for high density cultures used in biomanufacturing. Our membrane-free  technology has the has the following capabilities:

• Clog-free – No biofouling.
• Ultra-high density – Up to 100 million cells/mL.
• Enhances viability – Increase viability by 5% of bioreactor for every filtration operation.

We have combined several microfluidic components with programmable digital pneumatics, to achieve precise switching and controlled fluidic flows. These microfluidic switchboards can be further equipped with novel biosensors, creating a fully integrated platform for continuous processing. The integrated platform offers the following advantages:

• Minimal sample volumes and tube-free operations.
• High throughput and programmability.
• Miniaturization of multiple lab scale functionalities into microfluidic devices.
• High precision switching, control and sensitivity.
• Real-time data monitoring to ensure critical process parameters (CPPs) for in-process learning and automated online processes.
• Integrated microfluidic modules for functional versatility, diversity and optimal adaptive control.