Downstream Processing

• Purification process development from high throughput scale to pilot scale for bio-products

• We have established purification platforms with improved recovery, product purity and increased cost-effectiveness for both traditional and emerging modalities
• We offer comprehensive analytical platforms for in-process monitoring and final product QC to accelerate process development and ensure product quality and safety.
• Several patents and technological know-hows have been licensed to companies

Featured publications:

• Serene W Chen, Zi Ying Zheng, Farouq Bin Mahfut, Yuansheng Yang, Masahiro Ogino, Kazuo Okada, Kohei Sato and Wei Zhang (2023) Leveraging an advanced simulated moving bed approach to achieve 3-component separation for enhanced impurity removal in a non-affinity cation exchange capture step. PLoS ONE 18(1): e0280760
• Serene Chen, Hoi Kong Meng, Yang Yuansheng and Zhang Wei (2022) Excellent removal of knob‑into‑hole bispecific antibody byproducts and impurities in a single‑capture chromatography. Bioresources and Bioprocessing 9: 72
• Siew Yin Yin, Amrita Rai, Han Bin Pek, Dave Siak-Wei Ow and Zhang Wei (2021) New and efficient purification process for recombinant human insulin produced in Escherichia coli. Applied Microbiology and Biotechnology 105(24): 9137-9151
• Duy Tien Ta, Kai Ling Chu, Nur Izzati Bte Soonaan, Christine Chin, Say Kong Ng and Wei Zhang (2021) A new and simplified anion exchange chromatographic process for the purification of cell-grown influenza A H1N1 virus. Separation and Purification Technology 263: 118412
• Serene W Chen, Darryl Tan, Yuan Sheng Yang and Wei Zhang (2020) Investigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodies. mAbs 12 (1): 1718440