Our Capabilities
![CELL PROCESSING v2 CELL PROCESSING v2](/images/librariesprovider7/default-album/cell-processing-v2.png?sfvrsn=378deea7_0)
Cell Processing
Investigate different cell processing technologies from 2D/3D cell expansion to cell stimulation by using both single-use technologies and automated systems.
![ASEPTIC FLUID HANDLING AND MANAGEMENT ASEPTIC FLUID HANDLING AND MANAGEMENT](/images/librariesprovider7/default-album/aseptic-fluid-handling-management.png?sfvrsn=83a28b26_0)
ASEPTIC FLUID HANDLING & MANAGEMENT
Sterile and effective fluid handling steps with customised closed manifolds to accommodate diverse biomanufacturing requirements and applications.
![AUTOMATED SAMPLE PREPARATION AND MONITORING AUTOMATED SAMPLE PREPARATION AND MONITORING](/images/librariesprovider7/default-album/automated-sample-preparation-monitoring.png?sfvrsn=4cffdb8f_0)
AUTOMATED SAMPLE PREPARATION & MONITORING
Sample preparation with real-time product monitoring and integration of automated modules for dilution, dispensing, and protein measurement. Implementing advanced Process Analytical Technologies (PAT) in bioprocessing.
![RESEARCH FOR TISSUE MANUFACTURING RESEARCH FOR TISSUE MANUFACTURING](/images/librariesprovider7/default-album/research-for-tissue-manufacturing.png?sfvrsn=2d940625_0)
TISSUE BIOMANUFACTURING & CHARACTERIZATION
![BIOFABRICATION PLATFORMS BIOFABRICATION PLATFORMS](/images/librariesprovider7/default-album/biofabrication-platforms.png?sfvrsn=83d93b49_0)
BIOFABRICATION PLATFORMS
![TUNABLE NATURAL HYDROGEL FORMULATIONS TUNABLE NATURAL HYDROGEL FORMULATIONS](/images/librariesprovider7/default-album/tunable-natural-hydrogel-formulations92406a2c354045419bd3bbd467daa85f.png?sfvrsn=1c002f32_0)
TUNABLE NATURAL HYDROGEL FORMULATIONS
![DEVELOPMENT OF MICROTISSUE MODELS DEVELOPMENT OF MICROTISSUE MODELS](/images/librariesprovider7/default-album/development-of-microtissue-models.png?sfvrsn=11359833_0)
DEVELOPMENT OF MICROTISSUE MODELS
Our Technologies
![cGMP-IN-A-BOX cGMP-IN-A-BOX](/images/librariesprovider7/default-album/cgmp-in-a-box.png?sfvrsn=cf05812_0)
“cGMP-IN-A-BOX” - AUTOMATED AND FUNCTIONALLY CLOSED BIOREACTOR SYSTEM FOR DECENTRALIZED CELL THERAPY MANUFACTURING
- Automated: Automated cell and medium inoculation, medium change, sampling and harvesting
- Functionally closed: Minimum contamination risk in room condition
- Scalable: Direct process transfer from process development to manufacturing
![Aseptic Sampler Aseptic Sampler](/images/librariesprovider7/default-album/aseptic-sampler.jpg?sfvrsn=428de688_0)
AUTOMATED ASEPTIC SAMPLER SYSTEM FOR ONLINE SMALL-VOLUME CULTURE SAMPLING
- Automated and Aseptic: Programmable tubing and and valve system tested for aseptic culture sampling during cell therapy manufacturing
- Small volume sampling with zero dead-volume: Sample volume as low as 20µl
- Integrable: Able to be integrated with different culture vessels or bioreactor systems
![DECM DECM](/images/librariesprovider7/default-album/decmc15681c77b9c42528a271a15a2c1a1fd.png?sfvrsn=a0cac368_0)
DECELLULARIZED EXTRACELLULAR MATRIX (DECM) REACTOR
- Scalable, Clean and Compact: Able to decellularize animal, human, plant and fungi samples (50-400 g)
- Process Monitoring: Process controls employed to regulate the progress and optimize yield
- Application Focus: Cultivated meat and regenerative medicine applications
![ECM Sponge ECM Sponge](/images/librariesprovider7/default-album/ecm-sponge682f03d468884e6ba6dc184f72bbfc70.jpg?sfvrsn=18a74dcf_0)
EXTRACELLULAR MATRIX (ECM) SPONGE
- Biofabrication: Enables biofabrication of natural biomaterial into a porous sponge-like scaffold for tissue manufacturing applications
- Controllable: Range of pore size and the degradation rate of the cell culture scaffolds adjustable to match structure and regenerative speed of the different tissues
![Edible Scaffolds Edible Scaffolds](/images/librariesprovider7/default-album/edible-scaffolds.jpg?sfvrsn=81e8a53f_0)
EDIBLE SCAFFOLDS FOR CULTIVATED MEAT
- Microarchitecture: Access and exploit microarchitecture and morphologies in plants
- Applicable: To various species, including plants, fungi, and fruits, highly versatile
- Configurable: Readily shaped into various forms and sizes to fit to culture configurations
Our Track Record
Featured publications:
- Wee Swan Yap, Deepak Choudhury and Ratima Suntornnond (2023) Towards biomanufacturing of cultured meat. Trends in Biotechnology 41(3):292-294
- Sixun Chen, Ahmad Amirul Bin Abdul Rahim, Who‑Whong Wang, Rachael Cheong, Akshaya V. Prabhu, Jerome Zu Yao Tan, May Win Naing, Han Chong Toh & Dan Liu (2022) In-Situ Scalable Manufacturing of Epstein–Barr Virus-Specific T-Cells Using Bioreactor with an Expandable Culture Area (BECA). Scientific Reports 12: 7045
- Ying Ying Wu, Jia Sheng Zach Lee, Sixun Chen and Dan Liu (2022) Sterile Fluid Transfer for Cell Therapy Manufacturing-The Value of Multiple-Use Aseptic Connector. Frontiers in Bioengineering and Biotechnology-Biomaterials 9: 806677
- Weng Wan Chan, Fang Yu, Quang Bach Le, Sixun Chen, Marcus Yee and Deepak Choudhury (2021) Towards Biomanufacturing of Cell-Derived Matrices International Journal of Molecular Sciences 22(21): 11929
- Ying Y Wu, Dan Liu and May W Naing (2021) Development of A Closed and Automated Bioreactor Technology for Cell Therapy Manufacturing - A Sharing of Our Journey Regenerative Medicine 15(12) Commentary
- Harish K. Handral , Shi Hua Tay, Weng Wan Chan and Deepak Choudhury (2020) 3D Printing of cultured meat products. Critical Reviews in Food Science and Nutrition 1-10
- Liu Dan, Chen Sixun and May Win Naing (2020) A Review of Manufacturing Capabilities of Cell Spheroid Generation Technologies and Future Development. Biotechnology and Bioengineering 118(2): 542-554
- Deepak Choudhury, Marcus Yee, Zach Lee Jia Sheng, Ahmad Amirul and May Win Naing (2020) Decellularization systems and devices: State-of-the-art. Acta Biomaterialia 115: 51–59
Landmark Patent & IP:
- Connector Component And Connector System (2022)
- Liquid Sampling Device (2022)
- Methods and apparatus for decellularization of biological tissues and organs (2022)
- Device for cell culture and method for culturing cells (2018)
- Method And System For Monitoring Activity Of An Animal (2015)
The Team
![Deepak Choudhury v2 Deepak Choudhury v2](/images/librariesprovider7/default-album/deepak-choudhury-v2.jpg?sfvrsn=bdfee4cc_0)
Dr Deepak Choudhury
deepak_choudhury@bti.a-star.edu.sg
Principal Scientist I
PhD in Bioengineering (2012), National University of Singapore, Singapore
Research Focus / Interest
- Biomanufacturing process/platform development for biomaterials extraction from animals, plants, bacteria, algae, and fungi
- Development of scaffolds/substrates/inks for regenerative medicine and cultivated meat manufacturing
- Scale-up spinning, patterning, and printing of biomaterials
- Development of tissue manufacturing devices and platforms including Organ-on-Chips
![Liu Dan Liu Dan](/images/librariesprovider7/default-album/liu-dan.jpg?sfvrsn=cede1478_0)
Dr Liu Dan
liu_dan@bti.a-star.edu.sg
Senior Scientist II
PhD in Tissue Engineering (2012), Nanyang Technological University, Singapore
Research Focus / Interest
- Single-use technologies
- Devices for scaling-up and –out of cell therapy and cell-derived product manufacturing,
- Devices for biological, bioprocessing and biomedical applications
![Chen Sixun Chen Sixun](/images/librariesprovider7/default-album/chen-sixun.jpg?sfvrsn=cac631a_0)
Dr Chen Sixun
chen_sixun@bti.a-star.edu.sg
Senior Scientist I
PhD in Chemical Biology (2017), Harvard University, United States of America
Research Focus / Interest
- Process optimization and validation in bio-manufacturing
- Scaling of bioprocess for manufacturing
![Le Quang Bach Le Quang Bach](/images/librariesprovider7/default-album/le-quang-bach.jpg?sfvrsn=5b427c94_0)
Dr Le Quang Bach
quang_bach_le@bti.a-star.edu.sg
Senior Scientist I
PhD in Biomedical Engineering (2018), University of Maastricht, The Netherlands
Research Focus / Interest
- Developing cell-derived matrix platforms for tissue manufacturing
- Development of biomaterial formulations/hydrogels/bioinks
- Medical devices for orthopaedic applications
![Ratima Suntornnond Ratima Suntornnond](/images/librariesprovider7/default-album/ratima-suntornnond20c547457a1f4f6091d721fca5141e7e.jpg?sfvrsn=7bda085b_0)
Dr Ratima Suntornnond
ratima_suntornnond@bti.a-star.edu.sg
Scientist
PhD in Tissue engineering (2018), Nanyang Technological University, Singapore
Research Focus / Interest
- Development of natural and synthetic biomaterial formulations, hydrogels and bioinks
- Development of scaffolds, substrates and hydrogels for cultured meat
- Bioprinting/biofabrication processes for cellular agriculture and tissue engineering
![Tan Dai Nguyen Tan Dai Nguyen](/images/librariesprovider7/default-album/tan-dai-nguyen.jpg?sfvrsn=ac9396f9_0)
Dr Tan Dai Nguyen
tan_dai_nguyen@bti.a-star.edu.sg
Scientist
PhD in Mechanical Engineering (2021), Nanyang Technological University, Singapore
Research Focus / Interest
- Instrument and system development for cell manufacturing and advanced bioprocess
- Medical devices for biomedical applications