"Translating MSC exosomes into pharmaceuticals" (TEx2Pharm) is a programme that aims to develop potency assays necessary to manufacture mesenchymal stem cell (MSC) exosome drugs. Exosome attributes most relevant to their therapeutic potency, or mechanism of action, will be identified and quantified for each disease target, in line with guidelines from the regulatory bodies. We are focused on four areas – cardiovascular, orthopaedic, immune and ophthalmologic diseases – all highly tractable to MSC exosomes in animal models and will further identify exosome-associated therapeutic processes in a non-biased approach through metabolomic profiling of the disease models. Exosome-associated processes will then be mapped to attributes in the exosome proteome. TEx2Pharm will evaluate the MSC exosome proteins for bioactivity and develop the potency assays required to release the drug products for clinical testing or therapeutic use.
Landmark IP
Characterisation & Potency Tests for Exosome Products:
Cytotherapy: Critical Considerations for the Development of Potency Tests for Therapeutic Applications of Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles
https://doi.org/10.1016/j.jcyt.2021.01.001
Pharmaceuticals: Assessment of Tumorigenic Potential in Mesenchymal-Stem/Stromal-Cell-Derived Small Extracellular Vesicles (MSC-sEV)
https://www.mdpi.com/1424-8247/14/4/345
Cardio Disease:
Frontiers in Cardiovascular Medicine: Systemic Mesenchymal Stem Cell-Derived Exosomes Reduce Myocardial Infarct Size: Characterization With MRI in a Porcine Model
https://www.frontiersin.org/articles/10.3389/fcvm.2020.601990/full
Orthopaedic disease:
Journal of Arthroscopic and Related Surgery: Intra-Articular Injections of Mesenchymal Stem Cell Exosomes and Hyaluronic Acid Improve Structural and Mechanical Properties of Repaired Cartilage in a Rabbit Model
https://doi.org/10.1016/j.arthro.2020.03.031
Skin disease:
International Journal of Molecular Sciences: Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation
https://www.mdpi.com/1422-0067/22/2/720
Patents
- Mesenchymal Stem Cell Conditioned Medium
- Mesenchymal Stem Cell Particles (Exosome)
- MSC Exosome Biochemical Properties
- MSC exosome restores tissue homeostasis in disease or injury
- MSC Exosome Homeostasis (EB + GvHD)