The Protein Analytics laboratory hosts a repertoire of instrumentation for protein identification, quantitative protein expression profiling and mapping of post translational modifications. 2D Gel electrophoresis is used to separate protein mixtures. Replicate gel maps are compared and differentiating proteins are isolated, digested and identified by mass spectrometry (MS). Metabolic labelling of proteins with stable isotopes and peptide isobaric tagging is used to quantitatively compare the expression levels of proteins by MS. Tandem MS is performed to obtain peptide sequence information to identify proteins and to quantify labelled peptides.