A. Mark RICHARDS

 

RESEARCH

Neurohormonal regulation of the circulation in health and disease; biomarkers of cardiac injury; clinical observational studies and clinical therapeutic trials in cardiovascular disease; preclinical mechanistic studies of vasoactive peptides; clinical application of cardiovascular diagnostic and prognostic biomarkers; prognostic value of genetic variation within cardiovascular systems.

Selected Publications

• PEMBERTON CJ,SIRIWARDENA M,KLEFFMANN T,RUYGROK P,PALMER SC, YANDLE TG,RICHARDS AM First identification of circulating preproANP signal peptide fragments in man: initial assessment as cardiovascular biomarkers Clin Chem (in press) 2012. Abstract
• SCOTT NJA, CAMERON VA, 2. RAUDSEPP S, LEWIS LK, SIMPSON ER, RICHARDS AM, ELLMERS LJ. Generation and Characterization of a novel Mouse Model of the Metabolic Syndrome: Apolipoprotein E and Aromatase double knockout mice. Am J Physiol:Endocrinol & Metab (in press) 2012. Abstract
• ELLIS KL, FRAMPTON CM, DOUGHTY RN, WHALLEY GA,ELLIS CJ, PILBROW AP, SKELTON L, THOMSON J, YANDLE TG, TROUGHTON RW, RICHARDS AM, CAMERON VA. Genomic Risk Variants at 1p13.3, 1q41 and 3q22.3 are Associated with Subsequent Cardiovascular Outcomes in Healthy Controls and in Established Coronary Artery Disease Circulation: Cardiovascular Genetics 2011;4:636-646. Abstract
• MAISEL A, XUE Y,SHAH K,MUELLER C, NOWAK R, PEACOCK F, PONIKOWSKJI P,MOCKEL M, HOGAN C,WU AHB, RICHARDS M, CLOPTON P. FILIPPATOS GS, DI SOMMA S, ANAND I, NG L, DANIELS LB, NEATH S-X, CHRISTENSON R, POTOCKI M, McCORD J, TERRACIANOS G, KREMASTINOS D, HARTMANN O, VON HAELING S, BERGMANN A, MORGENTHALER NG, ANKER SD. Increased 90-Day Mortality in Acute Heart Failure Patients with Elevated Copeptin:Secondary Results from the Biomarkers in Acute Heart Failure (BACH) Study Circ:Heart Failure (in press) 2011 Abstract
• The Survival of Patients with Heart Failure with Preserved or Reduced Left Ventricular Ejection Fraction: an Individual Patient Data Meta-analysis. Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) Eur Heart J (member Steering Committee) 2011 doi:10.1093/eurheartj/ehr254. Abstract
• HILDEBRANDT P, COLLINSON P, FUAT A, GAZE D, GUSTAFSSON F, JANUZZI J, ROSENBERG J, SENIOR R, RICHARDS AM. Age-dependent values of NT-proBNP are superior to a Single Cut-point for Ruling out Heart Failure in Primary Care: The International Collaborative study of Natriuretic peptides in Primary Care (ICON-PC). Eur H J 2010;31;1881-9. Abstract
• PALMER BR, JARVIS MD, PILBROW AP, ELLIS KL, FRAMPTON CM, SKELTON L, YANDLE TG, DOUGHTY RN, WHALLEY GA, ELLIS CJ, TROUGHTON RW, CAMERON VA. Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort. Am Heart J 2008;156:752-8. Abstract
• LITTLEJOHN MD, PALMER BR, RICHARDS AM, FRAMPTON CM, PILBROW AP, TROUGHTON RW, CAMERON VA, KENNEDY MA. Ile164 variant of beta 2- adrenoceptor does not influence outcome in heart failure but may interact with beta blocker treatment. Eur J Heart Failure 2008;10:55-59. Abstract
• PILBROW AP, PALMER BR, FRAMPTON CM, YANDLE TG, TROUGHTON RW, CAMPBELL E, SKELTON L, LAINCHBURY JG, RICHARDS AM, CAMERON VA. Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure. Hypertension 2007;49:322-327. Abstract