Martin Lloyd HIBBERD

 

RESEARCH

My current research interests cover both pathogen and host aspects of infectious disease, understanding how microbial agents causes the observed disease (including pathogen identification and sequence characterization) and why specific individuals are susceptible to the disease (using host genetics on a genomic scale). Approaching infectious disease from these two directions also allows specific host pathogen responses to be investigated (utilizing RNA microarrays), both in patients and model systems. This work aims to identify key host responses to specific pathogens that could be targeted by new therapies. Current disease areas include, Dengue, TB, Kawasaki Disease, Meningococcal disease, respiratory syncytial virus and Inflammatory Bowel Disease

Selected Publications

• Lee GH, Tan BH, Teo EC, Lim SG, Dan YY, Wee A, Aw PP, Zhu Y, Hibberd ML, Tan CK, Purdy MA, Teo CG "Chronic Infection With Camelid Hepatitis E Virus in a Liver-transplant Recipient Who Regularly Consumes Camel Meat and Milk." Gastroenterology 2015 Nov 6 Abstract
• Sim S, Aw PP, Wilm A, Teoh G, Hue KD, Nguyen NM, Nagarajan N, Simmons CP, Hibberd ML "Tracking Dengue Virus Intra-host Genetic Diversity during Human-to-Mosquito Transmission." PLoS Negl Trop Dis 2015 Sep ; 9(9) : e0004052 Epub 2015 Sep 1 Abstract
• Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton MS, Hibberd ML, Kern F, Langford PR, Ling L, Mlotha R, Ottenhoff TH, Pienaar S, Pillay V, Scott JA, Twahir H, Wilkinson RJ, Coin LJ, Heyderman RS, Levin M, Eley B "Diagnosis of childhood tuberculosis and host RNA expression in Africa." N Engl J Med 2014 May 1 ; 370(18) : 1712-23 Abstract
• Hoang LT, Shimizu C, Ling L, Naim AN, Khor CC, Tremoulet AH, Wright V, Levin M, Hibberd ML, Burns JC "Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease." Genome Med 2014 ; 6(11) : 541 Epub 2014 Nov 20 Abstract
• Simões EA, Patel C, Sung WK, Lee CW, Loh KH, Lucero M, Nohynek H, Nai G, Thien PL, Koh CW, Chan YS, Ma J, Maurer-Stroh S, Carosone-Link P, Hibberd ML, Wong CW "Pathogen chip for respiratory tract infections." J Clin Microbiol 2013 Mar ; 51(3) : 945-53 Epub 2013 Jan 9 Abstract
• Heijtz RD, Wang S, Anuar F, Qian Y, Björkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S "Normal gut microbiota modulates brain development and behavior." Proc Natl Acad Sci U S A 2011 Jan 31 Abstract
• Khor CC, Chau TN, Pang J, Davila S, Long HT, Ong RT, Dunstan SJ, Wills B, Farrar J, Van Tram T, Gan TT, Binh NT, Tri LT, Lien LB, Tuan NM, Tham NT, Lanh MN, Nguyet NM, Hieu NT, Van N Vinh Chau N, Thuy TT, Tan DE, Sakuntabhai A, Teo YY, Hibberd ML, Simmons CP "Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1." Nat Genet 2011 Oct 16 Epub 2011 Oct 16 Abstract
• Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, Yeung RS, Tan DE, Sim KS, Wang JJ, Wong TY, Pang J, Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park IS, Lee JK, Wu JY, Levin M, Burns JC, Burgner D, Kuijpers TW, Hibberd ML, Lau YL, Zhang J, Ma XJ, Liu F, Wu L, Yoo JJ, Hong SJ, Kim KJ, Kim JJ, Park YM, Hong YM, Sohn S, Jang GY, Ha KS, Nam HK, Byeon JH, Yun SW, Han MK, Lee KY, Hwang JY, Rhim JW, Song MS, Lee HD, Kim DS, Lee JM, Chang JS, Tsai FJ, Liang CD, Chen MR, Chi H, Chiu NC, Huang FY, Chang LY, Huang LM, Kuo HC, Huang KP, Lee ML, Hwang B, Huang YC, Lee PC, Odam M, Christiansen FT, Witt C, Goldwater P, Curtis N, Palasanthiran P, Ziegler J, Nissen M, Nourse C, Kuipers IM, Ottenkamp JJ, Geissler J, Biezeveld M, Tacke C, Filippini L, Brogan P, Klein N, Shah V, Dillon M, Booy R, Shingadia D, Bose A, Mukasa T, Tulloh R, Michie C, Newburger JW, Baker AL, Rowley AH, Shulman ST, Mason W, Takahashi M, Melish ME, Tremoulet AH, Viswanathan A, Rochtchina E, Attia J, Scott R, Holliday E, Harrap S "Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease." Nat Genet 2011 Nov 13 Epub 2011 Nov 13 Abstract
• Lee VJ, Yap J, Cook AR, Chen MI, Tay JK, Tan BH, Loh JP, Chew SW, Koh WH, Lin R, Cui L, Lee CW, Sung WK, Wong CW, Hibberd ML, Kang WL, Seet B, Tambyah PA "Oseltamivir Ring Prophylaxis for Containment of 2009 H1N1 Influenza Outbreaks." N Engl J Med 2010 Jun 10 ; 362(23) : 2166-2174 Abstract
• Davila S, Wright VJ, Khor CC, Sim KS, Binder A, Breunis WB, Inwald D, Nadel S, Betts H, Carrol ED, de Groot R, Hermans PW, Hazelzet J, Emonts M, Lim CC, Kuijpers TW, Martinon-Torres F, Salas A, Zenz W, Levin M, Hibberd ML "Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease." Nat Genet 2010 Aug 8 Epub 2010 Aug 8 Abstract