Nigel CHOU Shijie
RESEARCH
We work on algorithms and methods to analyse and interpret data from emerging spatial omics technologies that uncover both the molecular profiles and spatial context of cells in a tissue. There is pressing need for algorithms specifically designed for this type of data. Important problems include: image analysis and cell segmentation, spatially aware clustering of cell types, segmentation of tissues into spatial domains, cell-cell interactions, and many more. Our goal is to develop novel, relevant and scalable approaches using the latest machine-learning techniques, which will empower users of spatial omics technologies to extract useful biological insights from their data. We work closely with groups within GIS and A*STAR that are developing new spatial omics technologies and applying them to address a wide variety of biological and clinical problems.
We are currently hiring research officers. If you are interested, please contact us at email: Nigel_Chou@gis.a-star.edu.sg.
Selected Publications
- Goh, J.J.L.*, Chou, N.*, Seow, W.Y. et al. Highly specific multiplexed RNA imaging in tissues with split-FISH. Nat Methods 17, 689–693 (2020). https://doi.org/10.1038/s41592-020-0858-0
- Stevens, M. *, Maire, C. *, Chou, N.*, Murakami M.*, Knoff D., et al. Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate. Nat Biotechnol 34, 1161–1167 (2016). https://doi.org/10.1038/nbt.3697
- N. Chou, J. Wu, J. Bai Bingren, A. Qiu and K. Chuang, "Robust Automatic Rodent Brain Extraction Using 3-D Pulse-Coupled Neural Networks (PCNN)," in IEEE Transactions on Image Processing, vol. 20, no. 9, pp. 2554-2564, Sept. 2011, doi: 10.1109/TIP.2011.2126587.
- N. Chou, J. A. Izatt and S. Farsiu, "Generalized pseudo-polar Fourier grids and applications in registering ophthalmic optical coherence tomography images," 2009 Conference Record of the Forty-Third Asilomar Conference on Signals, Systems and Computers, Pacific Grove, CA, 2009, pp. 807-811, doi: 10.1109/ACSSC.2009.5469972.
A*STAR celebrates International Women's Day
From groundbreaking discoveries to cutting-edge research, our researchers are empowering the next generation of female science, technology, engineering and mathematics (STEM) leaders.
Get inspired by our #WomeninSTEM