Research
By explicitly recognizing the importance of individual and population-level genetic variations and other molecular factors in determining or predicting clinical outcomes, Precision Medicine (PM) promises to transform how we assess disease risk, deliver more accurate diagnoses, and tailor appropriate therapies while minimizing treatment-related side effects. To address the challenge of big data analytics and integrative omics for PM, four institutions have come together to form the Centre for Big Data and Integrative Genomics (c-BIG).
As the Programme Manager for c-BIG, Dr. Bertin coordinates efforts and tracks progress across the centre's four partner institutions (GIS, BII, IHPC, I2R), oversees the deployment of the multi-institutional centre’s data acquisition, storage, and analytic capacities for large-scale clinical and research omics, and drives industry collaborations related to c-BIG infrastructure.
Links
Centre for Big Data and Integrative Genomics (c-BIG)
National Precision Medicine Programme
Selected Publications
- Hon CC*, Ramilowski JA*, Harshbarger J*, Bertin N*, Rackham OJ*, Gough J, Denisenko E, Schmeier S, Poulsen TM, Severin J, Lizio M, Kawaji H, Kasukawa T, Itoh M, Burroughs AM, Noma S, Djebali S, Alam T, Medvedeva YA, Testa AC, Lipovich L, Yip CW, Abugessaisa I, Mendez M, Hasegawa A, Tang D, Lassmann T, Heutink P, Babina M, Wells CA, Kojima S, Nakamura Y, Suzuki H, Daub CO, de Hoon MJ, Arner E, Hayashizaki Y, Carninci P, Forrest AR. An atlas of human long non-coding RNAs with accurate 5' ends. Nature 2017. Abstract
- Severin J, Lizio M, Harshbarger J, Kawaji H, Daub, Hayashizaki Y, Bertin N†, Forrest AR†. Interactive visualization and analysis of large-scale sequencing datasets using ZENBU. Nat Biotechnol 2014. Abstract
- Plessy C*†, Bertin N*†, Takahashi H, Simone R, Salimullah M, Lassmann T, Vitezic M, Severin J, Olivarius S, Lazarevic D, Hornig N, Orlando V, Bell I, Gao H, Dumais J, Kapranov P, Wang H, Davis CA, Gingeras TR, Kawai J, Daub CO, Hayashizaki Y, Gustincich S, Carninci P†. Linking promoters to functional transcripts in small samples with nanoCAGE and CAGEscan. Nat Methods 2010. Abstract
- Han JD, Bertin N, Hao T, Goldberg DS, Ber riz GF, Zhang LV, Dupuy D, Walhout AJ, Cusick ME, Roth FP, Vidal M. Evidence for dynamically organized modularity in the yeast protein-protein interaction network. Nature 2004. Abstract
- Li S*, Armstrong CM*, Bertin N*, Ge H*, Milstein S*, Boxem M*, Vidalain PO*, Han JD*, Chesneau A, Hao T, Goldberg DS, Li N, Martinez M, Rual JF, Lamesch P, Xu L, Tewari M, Wong SL, Zhang LV, Berriz GF, Jacotot L, Vaglio P, Reboul J, Hirozane-Kishikawa T, Li Q, Gabel HW, Elewa A, Baumgartner B, Rose DJ, Yu H, Bosak S, Sequerra R, Fraser A, Mango SE, Saxton WM, Strome S, Van Den Heuvel S, Piano F, Vandenhaute J, Sardet C, Gerstein M, Doucette-Stamm L, Gunsalus KC, Harper JW, Cusick ME, Roth FP, Hill DE, Vidal M. A map of the interactome network of the metazoan C. elegans. Science 2004. Abstract