OUR SCIENCE

Genomic Medicine

We seek to understand the relationship between genetic variation and disease phenotype on a population scale. Using both hypothesis-driven investigations and unbiased genome-wide interrogations, we are working towards identifying genomic regions or genes whose natural variations influence disease predisposition, progression and treatment outcomes.

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Precision Oncology

We integrate genomic information from biological and clinical studies to uncover genetic/epigenetic mechanisms driving tumourigenesis and to develop novel approaches to tackle problems such as therapeutic resistance and tumor recurrence.

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Infectious Diseases

GIS has utilised cutting edge genomic technology platforms to investigate infectious diseases from multiple perspectives. By looking at the genomes of both the pathogen and the host, together with their transcriptomic responses, we have enabled a rapid understanding of the host pathogen interaction during infectious diseases.

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Regenerative Medicine

The application of genomic technologies to explore stem cell biology has been a pillar of research at the GIS since its inception. Now we look to directed differentiation of stem cells to generate human cells and multi-cellular tissues in a culture dish to model human biology and disease.

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Computational & Systems Biology

We integrate and analyze large complex data sets to derive a systems understanding of biological processes. Our scientists bring to bear a range of expertise in biology, computer science, mathematics, and statistics to solve problems in genomic biology.

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Synthetic Biology

The Synthetic Biology group explores new avenues of genomic discovery based on biological engineering. Our work is catalyzed by the next generation of molecular reagents for manipulating genomes. We seek to improve existing genome editing tools, build new ones, and implement them in novel ways.

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Translational Initiatives

GIS is making a direct impact on health through its efforts to understand disease particularly prevalent in Asia. Our research in this area allows us to interface with the local clinician community and together reach out to industries. We have several large scale projects that position us to make "bench to bedside" tangible. The following programmes aim to lead to implementation of genomics technologies in the clinic.

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Technology Platforms

The GIS has a wide range of technologies used in modern genomic and cellular biology investigations. Advanced research methods, and the dedicated equipment designed to perform these methods, allows for new approaches to tackle challenging and new biological questions, opening up new vistas for exploration. With our technology platforms, we support genomics research across multiple A*STAR institutes, universities, hospitals, industries as well as international partners.

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