Link to slides : BII Talk - Sarah Harris - 4 Nov 2022** Please note that the materials are not meant to be modified/reproduced/circulated without permission. Speaker : Prof. Sarah Anne Harris, School of Physics and Astronomy, University of Leeds Title : Mesoscale Biomolecular Simulation with Fluctuating Finite Element Date : 4 November 2022 (Friday), 4.00pm to 5.30pmAbstract : Analysis Biophysical techniques such as cryo-EM/ET are now revealing highly organised super-macromolecular architectures at the length-scale directly above that of single molecules, and so there is a need for new computational tools to interpret these experiments. We have developed our own modelling software known as Fluctuating Finite Element Analysis (FFEA) that provides a continuum mechanics description of proteins, and which uses biophysical experimental information, such as electron microscopy data, as input to the calculations. We are using this program to model the action of molecular motors such as myosin and dynein.Speaker details : Prof Sarah Anne Harris (SAH) is a Principal Investigator in the School of Physics and Astronomy and the Astbury Centre for Structural and Molecular Biology at the University of Leeds. Her research aims to understand the mechanism underlying biological processes such as molecular recognition, DNA packing and the operation of molecular motors. She uses simulations of biomolecules on the both the atomistic and mesoscales, and is part of core team developing the Fluctuating Finite Element Analysis (FFEA) software for mesoscale simulation at Leeds. She has a strong interest in High Performance Computing (HPC), and promotes its use in the biosciences through the Computational Collaborative Project for Biomolecular Simulation (CCPBioSim).